[HTML][HTML] Fatty acid synthase modulates homeostatic responses to myocardial stress
Fatty acid synthase (FAS) promotes energy storage through de novo lipogenesis and
participates in signaling by the nuclear receptor PPARα in noncardiac tissues. To determine
if de novo lipogenesis is relevant to cardiac physiology, we generated and characterized
FAS knockout in the myocardium (FASKard) mice. FASKard mice develop normally, manifest
normal resting heart function, and have normal cardiac PPARα signaling as well as fatty acid
oxidation. However, they decompensate with stress. Most die within 1 h of transverse aortic …
participates in signaling by the nuclear receptor PPARα in noncardiac tissues. To determine
if de novo lipogenesis is relevant to cardiac physiology, we generated and characterized
FAS knockout in the myocardium (FASKard) mice. FASKard mice develop normally, manifest
normal resting heart function, and have normal cardiac PPARα signaling as well as fatty acid
oxidation. However, they decompensate with stress. Most die within 1 h of transverse aortic …