NOTCH1 PEST domain mutation is an adverse prognostic factor in B-CLL Correspondence.
P Sportoletti, S Baldoni, L Cavalli… - British journal of …, 2010 - search.ebscohost.com
P Sportoletti, S Baldoni, L Cavalli, B Del Papa, E Bonifacio, R Ciurnelli, AS Bell…
British journal of haematology, 2010•search.ebscohost.comThe article offers information on the advancement in the process of diagnosis, prognosis,
and treatment of B-cell chronic lymphocytic leukaemia (B-CLL). It mentions that high
expression of zeta-chain-associated protein kinase 70 (ZAP-70) and unmutated
immunoglobulin heavy variable (IGHV) genes are considered poor factors for prognosis. It
informs that NOTCH1 and PEST mutations are considered as marker of poor prognosis in a
minority of B-CLL patients.
and treatment of B-cell chronic lymphocytic leukaemia (B-CLL). It mentions that high
expression of zeta-chain-associated protein kinase 70 (ZAP-70) and unmutated
immunoglobulin heavy variable (IGHV) genes are considered poor factors for prognosis. It
informs that NOTCH1 and PEST mutations are considered as marker of poor prognosis in a
minority of B-CLL patients.
Abstract
The article offers information on the advancement in the process of diagnosis, prognosis, and treatment of B-cell chronic lymphocytic leukaemia (B-CLL). It mentions that high expression of zeta-chain-associated protein kinase 70 (ZAP-70) and unmutated immunoglobulin heavy variable (IGHV) genes are considered poor factors for prognosis. It informs that NOTCH1 and PEST mutations are considered as marker of poor prognosis in a minority of B-CLL patients.
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