[PDF][PDF] IKZF1 (Ikaros) Deletions in BCR-ABL1–Positive Acute Lymphoblastic Leukemia Are Associated With Short Disease-Free Survival and High Rate of …
G Martinelli, I Iacobucci, CT Storlazzi… - Journal of Clinical …, 2009 - academia.edu
Journal of Clinical Oncology, 2009•academia.edu
Purpose The causes of the aggressive nature of BCR-ABL1–positive adult acute
lymphoblastic leukemia (ALL) are unknown. To identify, at the submicroscopic level,
oncogenic lesions that cooperate with BCR-ABL1 to induce ALL, we performed an
investigation of genomic copy number alterations using single nucleotide polymorphism
array, genomic polymerase chain reaction, and sequencing of candidate genes.
lymphoblastic leukemia (ALL) are unknown. To identify, at the submicroscopic level,
oncogenic lesions that cooperate with BCR-ABL1 to induce ALL, we performed an
investigation of genomic copy number alterations using single nucleotide polymorphism
array, genomic polymerase chain reaction, and sequencing of candidate genes.
Purpose
The causes of the aggressive nature of BCR-ABL1–positive adult acute lymphoblastic leukemia (ALL) are unknown. To identify, at the submicroscopic level, oncogenic lesions that cooperate with BCR-ABL1 to induce ALL, we performed an investigation of genomic copy number alterations using single nucleotide polymorphism array, genomic polymerase chain reaction, and sequencing of candidate genes.
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