Pathogenesis of monoclonal gammopathy of undetermined significance and progression to multiple myeloma
A Zingone, WM Kuehl - Seminars in hematology, 2011 - Elsevier
Monoclonal gammopathy of undetermined significance (MGUS), including immunoglobulin
light chain only MGUS, is an age-dependent premalignant tumor that is present in about 4%
of Caucasian individuals over the age of 50 years. It is comprised of two different kinds of
tumors: about 15% lymphoid or lymphoplasmacytoid MGUS and the remainder plasma cell
MGUS. Plasma cell MGUS is stable but can sporadically progress to multiple myeloma (MM)
at an average rate of about 1% per year. Most, if not all, MM tumors are preceded by plasma …
light chain only MGUS, is an age-dependent premalignant tumor that is present in about 4%
of Caucasian individuals over the age of 50 years. It is comprised of two different kinds of
tumors: about 15% lymphoid or lymphoplasmacytoid MGUS and the remainder plasma cell
MGUS. Plasma cell MGUS is stable but can sporadically progress to multiple myeloma (MM)
at an average rate of about 1% per year. Most, if not all, MM tumors are preceded by plasma …
