[HTML][HTML] SOX11 expression is highly specific for mantle cell lymphoma and identifies the cyclin D1-negative subtype
A Mozos, C Royo, E Hartmann, D De Jong, C Baró… - …, 2009 - ncbi.nlm.nih.gov
A Mozos, C Royo, E Hartmann, D De Jong, C Baró, A Valera, K Fu, DD Weisenburger…
haematologica, 2009•ncbi.nlm.nih.govBackground Cyclin D1-negative mantle cell lymphoma is difficult to distinguish from other
small B-cell lymphomas. The clinical and pathological characteristics of patients with this
form of lymphoma have not been well defined. Overexpression of the transcription factor
SOX11 has been observed in conventional mantle cell lymphoma. The aim of this study was
to determine whether this gene is expressed in cyclin D1-negative mantle cell lymphoma
and whether its detection may be useful to identify these tumors.
small B-cell lymphomas. The clinical and pathological characteristics of patients with this
form of lymphoma have not been well defined. Overexpression of the transcription factor
SOX11 has been observed in conventional mantle cell lymphoma. The aim of this study was
to determine whether this gene is expressed in cyclin D1-negative mantle cell lymphoma
and whether its detection may be useful to identify these tumors.
Background
Cyclin D1-negative mantle cell lymphoma is difficult to distinguish from other small B-cell lymphomas. The clinical and pathological characteristics of patients with this form of lymphoma have not been well defined. Overexpression of the transcription factor SOX11 has been observed in conventional mantle cell lymphoma. The aim of this study was to determine whether this gene is expressed in cyclin D1-negative mantle cell lymphoma and whether its detection may be useful to identify these tumors.
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