Tracer studies in the rat demonstrate misdirected filtration and peritubular filtrate spreading in nephrons with segmental glomerulosclerosis
W Kriz, I Hartmann, H Hosser, B HA… - Journal of the …, 2001 - journals.lww.com
In two genetic models of “classic” focal segmental glomerulosclerosis (FSGS), the Milan
normotensive and the Fawn-hooded hypertensive rats, tracer studies were performed to test
the hypothesis that misdirected glomerular filtration and peritubular filtrate spreading are
relevant mechanisms that contribute to nephron degeneration in this disease. Two
exogenous tracers, lissamine green and horse spleen ferritin, were administered by
intravenous injection and subsequently traced histologically in serial kidney sections. In …
normotensive and the Fawn-hooded hypertensive rats, tracer studies were performed to test
the hypothesis that misdirected glomerular filtration and peritubular filtrate spreading are
relevant mechanisms that contribute to nephron degeneration in this disease. Two
exogenous tracers, lissamine green and horse spleen ferritin, were administered by
intravenous injection and subsequently traced histologically in serial kidney sections. In …