The hepatitis B virus X protein functionally interacts with CREB-binding protein/p300 in the regulation of CREB-mediated transcription
D Cougot, Y Wu, S Cairo, J Caramel, CA Renard… - Journal of biological …, 2007 - ASBMB
The hepatitis B virus infects more than 350 million people worldwide and is a leading cause
of liver cancer. The virus encodes a multifunctional regulator, the hepatitis B virus X protein
(HBx), that is essential for virus replication. HBx is involved in modulating signal transduction
pathways and transcription mediated by various factors, notably CREB that requires the
recruitment of the co-activators CREB-binding protein (CBP)/p300. Here we investigated the
role of HBx and its potential interaction with CBP/p300 in regulating CREB transcriptional …
of liver cancer. The virus encodes a multifunctional regulator, the hepatitis B virus X protein
(HBx), that is essential for virus replication. HBx is involved in modulating signal transduction
pathways and transcription mediated by various factors, notably CREB that requires the
recruitment of the co-activators CREB-binding protein (CBP)/p300. Here we investigated the
role of HBx and its potential interaction with CBP/p300 in regulating CREB transcriptional …
