[HTML][HTML] A Defect in Coenzyme Q Biosynthesis Is Responsible for the Respiratory Deficiency in Saccharomyces cerevisiae abc1Mutants
TQ Do, AY Hsu, T Jonassen, PT Lee… - Journal of Biological …, 2001 - ASBMB
Ubiquinone (coenzyme Q or Q) is an essential component of the mitochondrial respiratory
chain in eukaryotic cells. There are eight complementation groups of Q-
deficientSaccharomyces cerevisiae mutants designatedcoq1-coq8. Here we report that
COQ8 isABC1 (for Activity of bc 1 complex), which was originally isolated as a multicopy
suppressor of a cytochrome bmRNA translation defect (Bousquet, I., Dujardin, G., and
Slonimski, PP (1991) EMBO J. 10, 2023–2031). Previous studies of abc1 mutants suggested …
chain in eukaryotic cells. There are eight complementation groups of Q-
deficientSaccharomyces cerevisiae mutants designatedcoq1-coq8. Here we report that
COQ8 isABC1 (for Activity of bc 1 complex), which was originally isolated as a multicopy
suppressor of a cytochrome bmRNA translation defect (Bousquet, I., Dujardin, G., and
Slonimski, PP (1991) EMBO J. 10, 2023–2031). Previous studies of abc1 mutants suggested …