Free radicals, metals and antioxidants in oxidative stress-induced cancer

M Valko, CJB Rhodes, J Moncol, MM Izakovic… - Chemico-biological …, 2006 - Elsevier
Oxygen-free radicals, more generally known as reactive oxygen species (ROS) along with
reactive nitrogen species (RNS) are well recognised for playing a dual role as both
deleterious and beneficial species. The “two-faced” character of ROS is substantiated by
growing body of evidence that ROS within cells act as secondary messengers in intracellular
signalling cascades, which induce and maintain the oncogenic phenotype of cancer cells,
however, ROS can also induce cellular senescence and apoptosis and can therefore …