[HTML][HTML] A Natural Disruption of the Secretory Group II Phospholipase A2 Gene in Inbred Mouse Strains (∗)
BP Kennedy, P Payette, J Mudgett, P Vadas… - Journal of Biological …, 1995 - ASBMB
The synovial fluid or group II secretory phospholipase A 2 (sPLA 2) has been implicated as
an important agent involved in a number of inflammatory processes. In an attempt to
determine the role of sPLA 2 in inflammation, we set out to generate sPLA 2-deficient mice.
During this investigation, we observed that in a number of inbred mouse strains, the sPLA 2
gene was already disrupted by a frameshift mutation in exon 3. This mutation, a T insertion
at position 166 from the ATG of the cDNA, terminates out of frame in exon 4, resulting in the …
an important agent involved in a number of inflammatory processes. In an attempt to
determine the role of sPLA 2 in inflammation, we set out to generate sPLA 2-deficient mice.
During this investigation, we observed that in a number of inbred mouse strains, the sPLA 2
gene was already disrupted by a frameshift mutation in exon 3. This mutation, a T insertion
at position 166 from the ATG of the cDNA, terminates out of frame in exon 4, resulting in the …