Identification of the gene for a novel liver-related putative tumor suppressor at a high-frequency loss of heterozygosity region of chromosome 8p23 in human …
C Liao, M Zhao, H Song, K Uchida, KK Yokoyama, T Li - Hepatology, 2000 - Elsevier
Human chromosome 8p23 is known as a region that is associated with loss of
heterozygosity (LOH), which is frequently deleted in hepatocellular carcinoma (HCC)
tissues. We report here the characterization of a gene for a liver-related putative tumor
suppressor (LPTS) localized at 8p23, that was isolated by allelic-loss mapping and
positional candidate cloning. The expression of the gene for LPTS was ubiquitous in normal
human tissues, albeit at relatively low levels, whereas levels appeared to be significantly …
heterozygosity (LOH), which is frequently deleted in hepatocellular carcinoma (HCC)
tissues. We report here the characterization of a gene for a liver-related putative tumor
suppressor (LPTS) localized at 8p23, that was isolated by allelic-loss mapping and
positional candidate cloning. The expression of the gene for LPTS was ubiquitous in normal
human tissues, albeit at relatively low levels, whereas levels appeared to be significantly …
