The role of CXCR7/RDC1 as a chemokine receptor for CXCL12/SDF-1 in prostate cancer
J Wang, Y Shiozawa, J Wang, Y Wang, Y Jung… - Journal of Biological …, 2008 - ASBMB
Several reports have recently documented that CXCR7/RDC1 functions as a chemokine
receptor for SDF-1/CXCL12, which regulates a spectrum of normal and pathological
processes. In this study, the role of CXCR7/RDC1 in prostate cancer (PCa) was explored.
Staining of high density tissue microarrays demonstrates that the levels of CXCR7/RDC1
expression increase as the tumors become more aggressive. In vitro and in vivo studies with
PCa cell lines suggest that alterations in CXCR7/RDC1 expression are associated with …
receptor for SDF-1/CXCL12, which regulates a spectrum of normal and pathological
processes. In this study, the role of CXCR7/RDC1 in prostate cancer (PCa) was explored.
Staining of high density tissue microarrays demonstrates that the levels of CXCR7/RDC1
expression increase as the tumors become more aggressive. In vitro and in vivo studies with
PCa cell lines suggest that alterations in CXCR7/RDC1 expression are associated with …
