Expressions of Raldh3 and Raldh4 during zebrafish early development
D Liang, M Zhang, J Bao, L Zhang, X Xu, X Gao… - Gene Expression …, 2008 - Elsevier
Retinoic acid (RA) plays crucial roles in vertebrate embryogenesis. Four retinal
dehydrogenases (Raldhs) that are responsible for RA synthesis have been characterized in
mammals. However, only Raldh2 ortholog is identified in zebrafish. Here, we report the
identification of raldh3 and raldh4 genes in zebrafish. The predicted proteins encoded by
zebrafish raldh3 and raldh4 exhibit 70.0% and 73.5% amino acid identities with mouse
Raldh3 and Raldh4, respectively. RT-PCR analyses reveal that both raldh3 and raldh4 …
dehydrogenases (Raldhs) that are responsible for RA synthesis have been characterized in
mammals. However, only Raldh2 ortholog is identified in zebrafish. Here, we report the
identification of raldh3 and raldh4 genes in zebrafish. The predicted proteins encoded by
zebrafish raldh3 and raldh4 exhibit 70.0% and 73.5% amino acid identities with mouse
Raldh3 and Raldh4, respectively. RT-PCR analyses reveal that both raldh3 and raldh4 …