[HTML][HTML] Disulfide bond reduction of von Willebrand factor by ADAMTS‐13
HC Yeh, Z Zhou, H Choi, S Tekeoglu, W MAY III… - Journal of Thrombosis …, 2010 - Elsevier
See also Lenting PJ, Rastegarlari G. ADAMTS‐13: double trouble for von Willebrand factor.
This issue, pp 2775–7. Summary Background: von Willebrand factor (VWF) released from
endothelial cells is rich in ultra‐large (UL) multimers that are intrinsically active in binding
platelets, whereas plasma‐type VWF multimers require shear stress to be activated. This
functional difference may be attributed to thiols exposed on the surface of plasma‐type VWF
multimers, but not on ULVWF multimers. Shear stress induces the exposed thiols to form …
This issue, pp 2775–7. Summary Background: von Willebrand factor (VWF) released from
endothelial cells is rich in ultra‐large (UL) multimers that are intrinsically active in binding
platelets, whereas plasma‐type VWF multimers require shear stress to be activated. This
functional difference may be attributed to thiols exposed on the surface of plasma‐type VWF
multimers, but not on ULVWF multimers. Shear stress induces the exposed thiols to form …
