An ancestral haplotype defines susceptibility to doxorubicin nephropathy in the laboratory mouse
Z Zheng, P Pavlidis, S Chua, VD D'Agati… - Journal of the …, 2006 - journals.lww.com
Haplotype analysis was used to refine of the DOXNPH locus, which harbors the
susceptibility gene for doxorubicin (DOX; Adriamycin) nephropathy, a Mendelian form of
selective podocyte injury. Analysis of haplotype structure in three strains with contrasting
susceptibility (148 single-nucleotide polymorphisms at 101-kb spacing) was complementary
to analysis of recombinants in 176 F2 mice. For example, haplotype analysis but not meiotic
mapping could exclude the Abcc1 multidrug transporter, and this was confirmed further by …
susceptibility gene for doxorubicin (DOX; Adriamycin) nephropathy, a Mendelian form of
selective podocyte injury. Analysis of haplotype structure in three strains with contrasting
susceptibility (148 single-nucleotide polymorphisms at 101-kb spacing) was complementary
to analysis of recombinants in 176 F2 mice. For example, haplotype analysis but not meiotic
mapping could exclude the Abcc1 multidrug transporter, and this was confirmed further by …