The biogenesis of mitochondria depends on the coordinated expression of nuclear and
mitochondrial genomes. Consequently, the control of mitochondrial biogenesis and function
depends on extremely complex processes requiring a variety of well orchestrated regulatory
mechanisms. It is clear that the interplay of transcription factors and coactivators contributes
to the expression of both nuclear and mitochondrial respiratory genes. In addition, the
regulation of mitochondria biogenesis depends on proteins that, interacting with messenger …