Transforming growth factor-β induces renal epithelial jagged-1 expression in fibrotic disease
J Morrissey, G Guo, K Moridaira… - Journal of the …, 2002 - journals.lww.com
For elucidation of the mechanisms by which growth factors and cytokines affect renal
epithelial cells, gene array analysis of renal cells cultured in the presence of transforming
growth factor-β1 (TGF-β1) was performed. Many genes that were not previously considered
to be involved in renal cell biologic processes were affected, one of which was jagged-1.
The jagged ligand/notch receptor family controls the formation of boundaries between
groups of cells and regulates cell fates. On the basis of the array analysis, jagged-1 …
epithelial cells, gene array analysis of renal cells cultured in the presence of transforming
growth factor-β1 (TGF-β1) was performed. Many genes that were not previously considered
to be involved in renal cell biologic processes were affected, one of which was jagged-1.
The jagged ligand/notch receptor family controls the formation of boundaries between
groups of cells and regulates cell fates. On the basis of the array analysis, jagged-1 …