Molecular correlates of renal function in kidney transplant biopsies
S Bunnag, G Einecke, J Reeve… - Journal of the …, 2009 - journals.lww.com
The molecular changes in the parenchyma that reflect disturbances in the function of kidney
transplants are unknown. We studied the relationships among histopathology, gene
expression, and renal function in 146 human kidney transplant biopsies performed for
clinical indications. Impaired function (estimated GFR) correlated with tubular atrophy and
fibrosis but not with inflammation or rejection. Functional deterioration before biopsy
correlated with inflammation and tubulitis and was greater in cases of rejection. Microarray …
transplants are unknown. We studied the relationships among histopathology, gene
expression, and renal function in 146 human kidney transplant biopsies performed for
clinical indications. Impaired function (estimated GFR) correlated with tubular atrophy and
fibrosis but not with inflammation or rejection. Functional deterioration before biopsy
correlated with inflammation and tubulitis and was greater in cases of rejection. Microarray …
