[HTML][HTML] Early loss of renal transcripts in kidney allografts: relationship to the development of histologic lesions and alloimmune effector mechanisms
We sought to understand the epithelial response to the T-cell mediated inflammatory
process in kidney allograft rejection. Using microarrays, we studied transcriptome changes
of kidney parenchymal cells and their relationship to the development of pathologic lesions
such as tubulitis in mouse kidney allografts and isografts. Inflammatory infiltrate in allografts
developed by day 5, but tubulitis first appeared at day 7 and was severe by day 21. Using
microarrays, we selected 70 solute carrier transcripts with high renal parenchymal …
process in kidney allograft rejection. Using microarrays, we studied transcriptome changes
of kidney parenchymal cells and their relationship to the development of pathologic lesions
such as tubulitis in mouse kidney allografts and isografts. Inflammatory infiltrate in allografts
developed by day 5, but tubulitis first appeared at day 7 and was severe by day 21. Using
microarrays, we selected 70 solute carrier transcripts with high renal parenchymal …
