[HTML][HTML] Microarray analysis of rejection in human kidney transplants using pathogenesis-based transcript sets
TF Mueller, G Einecke, J Reeve, B Sis… - American journal of …, 2007 - Elsevier
Microarrays offer potential for objective diagnosis and insights into pathogenesis of allograft
rejection. We used mouse transplants to annotate pathogenesis-based transcript sets
(PBTs) that reflect major biologic events in allograft rejection—cytotoxic T-cell infiltration,
interferon-γ effects and parenchymal deterioration. We examined the relationship between
PBT expression, histopathologic lesions and clinical diagnoses in 143 consecutive human
kidney transplant biopsies for cause. PBTs correlated strongly with one another, indicating …
rejection. We used mouse transplants to annotate pathogenesis-based transcript sets
(PBTs) that reflect major biologic events in allograft rejection—cytotoxic T-cell infiltration,
interferon-γ effects and parenchymal deterioration. We examined the relationship between
PBT expression, histopathologic lesions and clinical diagnoses in 143 consecutive human
kidney transplant biopsies for cause. PBTs correlated strongly with one another, indicating …
