A number of cellular proteins have been identified as caspase targets during cell death,
including the PITSLRE protein kinases. These targets generally fall into one of three
possible categories: 1) other caspases, 2) proteins that are inactivated during apoptosis, and
3) proteins that are required for execution of the cell death program. However, not all
proteins are cleaved by caspases during apoptosis. Why only specific proteins are destined
to be processed by caspases during cell death is currently not clear. Here we show that …