Cloning and sequencing of a rabbit cDNA encoding an intestinal and kidney-specific Na+/H+ exchanger isoform (NHE-3).
CM Tse, SR Brant, MS Walker, J Pouyssegur… - Journal of Biological …, 1992 - ASBMB
We previously cloned, sequenced, and expressed two distinct mammalian Na+/H+
exchanger isoforms (NHE-1 and NHE-2). We report here the cloning of a composite cDNA
which encodes a third mammalian isoform (NHE-3), which is expressed specifically in
intestine and kidney. The protein deduced from the longest open reading frame of this
composite sequence has 832 amino acids with a calculated Mr of 92,747. The
hydrophobicity plot of NHE-3 is very similar to that of NHE-1 and NHE-2. NHE-3 is also …
exchanger isoforms (NHE-1 and NHE-2). We report here the cloning of a composite cDNA
which encodes a third mammalian isoform (NHE-3), which is expressed specifically in
intestine and kidney. The protein deduced from the longest open reading frame of this
composite sequence has 832 amino acids with a calculated Mr of 92,747. The
hydrophobicity plot of NHE-3 is very similar to that of NHE-1 and NHE-2. NHE-3 is also …
