A conserved non-homeodomain Hoxa9 isoform interacting with CBP is co-expressed with the 'typical'Hoxa9 protein during embryogenesis
A Dintilhac, R Bihan, D Guerrier, S Deschamps… - Gene Expression …, 2004 - Elsevier
Various Hox genes are known to produce alternative transcripts encoding different isoforms
whose physiological relevance during development is not yet understood. In this work, we
analysed two different Hoxa9 mRNAs encoding a full-length protein (Hoxa9) or a protein
lacking the homeodomain (Hoxa9T). First, we demonstrated that these transcripts are
conserved from birds to mammals. We then showed that both transcripts are present
throughout embryogenesis and that Hoxa9T transcript is particularly abundant in embryonic …
whose physiological relevance during development is not yet understood. In this work, we
analysed two different Hoxa9 mRNAs encoding a full-length protein (Hoxa9) or a protein
lacking the homeodomain (Hoxa9T). First, we demonstrated that these transcripts are
conserved from birds to mammals. We then showed that both transcripts are present
throughout embryogenesis and that Hoxa9T transcript is particularly abundant in embryonic …
