Failure of regeneration of the steatotic rat liver: disruption at two different levels in the regeneration pathway
M Selzner, PA Clavien - Hepatology, 2000 - journals.lww.com
Hepatic resection or transplantation in patients with fatty liver is associated with increased
morbidity and mortality. The regenerative capacity of fatty livers after major tissue loss is
unknown. Interleukin 6 (IL-6) is a potent inducer of hepatic regeneration in normal and
ischemic livers. Therefore, we studied hepatic regeneration at day 1, day 2, and day 4 in a
model of 70% hepatectomy in obese and lean Zucker rats, and obese Zucker rats pretreated
with recombinant interleukin 6 (rIL-6). The mitotic cycle in hepatocytes was investigated by 4 …
morbidity and mortality. The regenerative capacity of fatty livers after major tissue loss is
unknown. Interleukin 6 (IL-6) is a potent inducer of hepatic regeneration in normal and
ischemic livers. Therefore, we studied hepatic regeneration at day 1, day 2, and day 4 in a
model of 70% hepatectomy in obese and lean Zucker rats, and obese Zucker rats pretreated
with recombinant interleukin 6 (rIL-6). The mitotic cycle in hepatocytes was investigated by 4 …
