[HTML][HTML] γ2-adaptin, a novel ubiquitin-interacting adaptor, and Nedd4 ubiquitin ligase control hepatitis B virus maturation
M Rost, S Mann, C Lambert, T Döring… - Journal of biological …, 2006 - ASBMB
Hepatitis B virus (HBV) budding from infected cells is a tightly regulated process that
requires both core and envelope structures. Here we report that HBV uses cellular γ2-
adaptin and Nedd4, possibly in conjunction with ubiquitin, to coordinate its assembly and
release. In search of interaction partners of the viral L envelope protein, we previously
discovered γ2-adaptin, a putative endosomal sorting and trafficking adaptor of the adaptor
protein complex family. We now demonstrate that the viral core interacts with the same γ2 …
requires both core and envelope structures. Here we report that HBV uses cellular γ2-
adaptin and Nedd4, possibly in conjunction with ubiquitin, to coordinate its assembly and
release. In search of interaction partners of the viral L envelope protein, we previously
discovered γ2-adaptin, a putative endosomal sorting and trafficking adaptor of the adaptor
protein complex family. We now demonstrate that the viral core interacts with the same γ2 …
