Release of interleukins and other inflammatory cytokines by human adipose tissue is enhanced in obesity and primarily due to the nonfat cells
JN Fain - Vitamins & Hormones, 2006 - Elsevier
The white adipose tissue, especially of humans, is now recognized as the central player in
the mild inflammatory state that is characteristic of obesity. The question is how the
increased accumulation of lipid seen in obesity causes an inflammatory state and how this is
linked to the hypertension and type 2 diabetes that accompanies obesity. Once it was
thought that adipose tissue was primarily a reservoir for excess calories that were stored in
the adipocytes as triacylglycerols. In times of caloric deprivation these stored lipids were …
the mild inflammatory state that is characteristic of obesity. The question is how the
increased accumulation of lipid seen in obesity causes an inflammatory state and how this is
linked to the hypertension and type 2 diabetes that accompanies obesity. Once it was
thought that adipose tissue was primarily a reservoir for excess calories that were stored in
the adipocytes as triacylglycerols. In times of caloric deprivation these stored lipids were …