[HTML][HTML] Structure and substrate specificity of the Pim-1 kinase
AN Bullock, J Debreczeni, AL Amos, S Knapp… - Journal of Biological …, 2005 - ASBMB
The Pim kinases are a family of three vertebrate protein serine/threonine kinases (Pim-1,-2,
and-3) belonging to the CAMK (calmodulin-dependent protein kinase-related) group. Pim
kinases are emerging as important mediators of cytokine signaling pathways in
hematopoietic cells, and they contribute to the progression of certain leukemias and solid
tumors. A number of cytoplasmic and nuclear proteins are phosphorylated by Pim kinases
and may act as their effectors in normal physiology and in disease. Recent crystallographic …
and-3) belonging to the CAMK (calmodulin-dependent protein kinase-related) group. Pim
kinases are emerging as important mediators of cytokine signaling pathways in
hematopoietic cells, and they contribute to the progression of certain leukemias and solid
tumors. A number of cytoplasmic and nuclear proteins are phosphorylated by Pim kinases
and may act as their effectors in normal physiology and in disease. Recent crystallographic …