Diet-induced obesity in the rat: a model for gestational diabetes mellitus
K Holemans, S Caluwaerts, L Poston… - American journal of …, 2004 - Elsevier
OBJECTIVES: Obesity is one of the most important risk factors for the development of
gestational diabetes mellitus (GDM). However, in obese women, it is difficult to disentangle
the genetic and environmental contributions. The aim of this study was to investigate
whether diet-induced obesity results in GDM in rats with the same genetic background.
STUDY DESIGN: Female Wistar rats were fed a cafeteria-style diet (CAF) or the standard
control (C) diet from 70 days of age onward. After 4 weeks on the diets, subgroups of CAF …
gestational diabetes mellitus (GDM). However, in obese women, it is difficult to disentangle
the genetic and environmental contributions. The aim of this study was to investigate
whether diet-induced obesity results in GDM in rats with the same genetic background.
STUDY DESIGN: Female Wistar rats were fed a cafeteria-style diet (CAF) or the standard
control (C) diet from 70 days of age onward. After 4 weeks on the diets, subgroups of CAF …