Plasmin (ogen) promotes renal interstitial fibrosis by promoting epithelial-to-mesenchymal transition: role of plasmin-activated signals
G Zhang, KA Kernan, SJ Collins, X Cai… - Journal of the …, 2007 - journals.lww.com
Abstract Plasminogen (Plg) activator inhibitor-1 (PAI-1) is an important fibrosis-promoting
molecule. Whether this effect can be attributed to PAI-1's activity as an inhibitor of plasmin
generation is debated. This study was designed to investigate the role of Plg in renal fibrosis
using in vivo and in vitro approaches. Plg-deficient (Plg−/−) and wild-type (Plg+/+) C57BL/6
mice were subjected to unilateral ureteral obstruction or sham surgery (n= 8/group; sham,
days 3, 7, 14, and 21). Plg deficiency was confirmed by the absence of Plg mRNA, protein …
molecule. Whether this effect can be attributed to PAI-1's activity as an inhibitor of plasmin
generation is debated. This study was designed to investigate the role of Plg in renal fibrosis
using in vivo and in vitro approaches. Plg-deficient (Plg−/−) and wild-type (Plg+/+) C57BL/6
mice were subjected to unilateral ureteral obstruction or sham surgery (n= 8/group; sham,
days 3, 7, 14, and 21). Plg deficiency was confirmed by the absence of Plg mRNA, protein …
