Peritubular capillary loss is associated with chronic tubulointerstitial injury in human kidney: altered expression of vascular endothelial growth factor
YJ Choi, S Chakraborty, V Nguyen, C Nguyen, BK Kim… - Human pathology, 2000 - Elsevier
Chronic tubulointerstitial injury (CTI) including tubular atrophy and interstitial fibrosis
represents one major determinant for the progression of chronic renal disease regardless of
cause. Although peritubular capillaries (PTCs) are essential to maintain the normal structure
and function of renal tubules, little is known about the role of PTCs in the development of
CTI. The integrity of PTCs seems to be regulated by growth factors. Vascular endothelial cell
growth factor (VEGF) has recently been recognized as a potent regulator of angiogenesis …
represents one major determinant for the progression of chronic renal disease regardless of
cause. Although peritubular capillaries (PTCs) are essential to maintain the normal structure
and function of renal tubules, little is known about the role of PTCs in the development of
CTI. The integrity of PTCs seems to be regulated by growth factors. Vascular endothelial cell
growth factor (VEGF) has recently been recognized as a potent regulator of angiogenesis …
