For more than a century, a role for wound healing in the outgrowth of tumours has been
implied based on observations in both experimental and clinical studies. Wound healing can
be divided into stages of inflammatory, proliferative, repair and remodelling processes.
Through proper regulation of activation of epithelial, endothelial and inflammatory cells,
platelets and fibroblasts, and the production of growth factors, wounds heal and the various
cell types resume their normal function. In tumour growth, similar processes of cell activation …