[HTML][HTML] Protein kinase C and calcineurin synergize to activate IκB kinase and NF-κB in T lymphocytes
SA Trushin, KN Pennington… - Journal of Biological …, 1999 - ASBMB
The nuclear factor of κB (NF-κB) is a ubiquitous transcription factor that is key in the
regulation of the immune response and inflammation. T cell receptor (TCR) cross-linking is
in part required for activation of NF-κB, which is dependent on the phosphorylation and
degradation of IκBα. By using Jurkat and primary human T lymphocytes, we demonstrate
that the simultaneous activation of two second messengers of the TCR-initiated signal
transduction, protein kinase C (PKC) and calcineurin, results in the synergistic activation of …
regulation of the immune response and inflammation. T cell receptor (TCR) cross-linking is
in part required for activation of NF-κB, which is dependent on the phosphorylation and
degradation of IκBα. By using Jurkat and primary human T lymphocytes, we demonstrate
that the simultaneous activation of two second messengers of the TCR-initiated signal
transduction, protein kinase C (PKC) and calcineurin, results in the synergistic activation of …
