[HTML][HTML] Pathogenic Neisseria trigger expression of their carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1; previously CD66a) receptor on …
P Muenzner, M Naumann, TF Meyer… - Journal of Biological …, 2001 - ASBMB
Neisseria gonorrhoeae express opacity-associated (Opa) protein adhesins that mediate
binding to various members of the carcinoembryonic antigen-related cellular adhesion
molecule (CEACAM; previously CD66) receptor family. Although human umbilical vein
endothelial cells express little CEACAM receptor in vitro, we found neisserial infection to
induce expression of CEACAM1, CEACAM1-3L, and CECAM1-4L splice variants. This
mediates an increased Opa 52-dependent binding of gonococci by these cells. The induced …
binding to various members of the carcinoembryonic antigen-related cellular adhesion
molecule (CEACAM; previously CD66) receptor family. Although human umbilical vein
endothelial cells express little CEACAM receptor in vitro, we found neisserial infection to
induce expression of CEACAM1, CEACAM1-3L, and CECAM1-4L splice variants. This
mediates an increased Opa 52-dependent binding of gonococci by these cells. The induced …
