Expanded macrophage precursor populations in BXSB mice: possible reason for the increasing monocytosis in male mice
G Vieten, MR Hadam, H De Boer, A Olp… - Clinical immunology and …, 1992 - Elsevier
The BXSB mouse spontaneously develops an autoimmune disease that resembles human
systemic lupus erythematosus (SLE). During their lifetime, male BXSB mice show an
increasing monocytosis in the peripheral blood as opposed to their female littermates. This
monocytosis is unique among autoimmune-prone mice. To test the hypothesis that
alterations at the stem cell level may be responsible for this monocytosis, myeloid bone
marrow precursor cells were examined in both male and female BXSB mice from 4 to 40 …
systemic lupus erythematosus (SLE). During their lifetime, male BXSB mice show an
increasing monocytosis in the peripheral blood as opposed to their female littermates. This
monocytosis is unique among autoimmune-prone mice. To test the hypothesis that
alterations at the stem cell level may be responsible for this monocytosis, myeloid bone
marrow precursor cells were examined in both male and female BXSB mice from 4 to 40 …
