[HTML][HTML] Activation of protein kinase Cζ is essential for cytokine-induced metalloproteinase-1,-3, and-9 secretion from rabbit smooth muscle cells and inhibits …
S Hussain, JW Assender, M Bond, LF Wong… - Journal of Biological …, 2002 - ASBMB
Several matrix metalloproteinases (MMPs), including MMP-1,-3, and-9, mediate matrix
destruction during chronic inflammatory diseases such as arthritis and atherosclerosis. MMP
up-regulation by inflammatory cytokines involves interactions between several transcription
factors, including activator protein-1 and nuclear factor κB (NF-κB). The upstream regulatory
pathways are less well understood. We investigated the role of isoforms of protein kinase C
(PKC) in basic fibroblast growth factor-and interleukin-1α-mediated MMP production from …
destruction during chronic inflammatory diseases such as arthritis and atherosclerosis. MMP
up-regulation by inflammatory cytokines involves interactions between several transcription
factors, including activator protein-1 and nuclear factor κB (NF-κB). The upstream regulatory
pathways are less well understood. We investigated the role of isoforms of protein kinase C
(PKC) in basic fibroblast growth factor-and interleukin-1α-mediated MMP production from …
