Synchronized whole cell oscillations in mitochondrial metabolism triggered by a local release of reactive oxygen species in cardiac myocytes
Reactive oxygen species (ROS) and/or Ca 2+ overload can trigger depolarization of
mitochondrial inner membrane potential (ΔΨ m) and cell injury. Little is known about how
loss of ΔΨ m in a small number of mitochondria might influence the overall function of the
cell. Here we employ the narrow focal excitation volume of the two-photon microscope to
examine the effect of local mitochondrial depolarization in guinea pig ventricular myocytes.
Remarkably, a single local laser flash triggered synchronized and self-sustained oscillations …
mitochondrial inner membrane potential (ΔΨ m) and cell injury. Little is known about how
loss of ΔΨ m in a small number of mitochondria might influence the overall function of the
cell. Here we employ the narrow focal excitation volume of the two-photon microscope to
examine the effect of local mitochondrial depolarization in guinea pig ventricular myocytes.
Remarkably, a single local laser flash triggered synchronized and self-sustained oscillations …
