[HTML][HTML] (Xeno) estrogen sensitivity of smooth muscle BK channels conferred by the regulatory β1 subunit: a study of β1 knockout mice
GM Dick, KM Sanders - Journal of Biological Chemistry, 2001 - ASBMB
Estrogen and xenoestrogens (ie agents that are not steroids but possess estrogenic activity)
increase the open probability (P o) of large conductance Ca 2+-activated K+(BK) channels
in smooth muscle. The mechanism of action may involve the regulatory β1 subunit. We used
β1 subunit knockout (β1−/−) mice to test the hypothesis that the regulatory β1 subunit is
essential for the activation of BK channels by tamoxifen, 4-OH tamoxifen (a major
biologically active metabolite), and 17β-estradiol in native myocytes. Patch clamp recordings …
increase the open probability (P o) of large conductance Ca 2+-activated K+(BK) channels
in smooth muscle. The mechanism of action may involve the regulatory β1 subunit. We used
β1 subunit knockout (β1−/−) mice to test the hypothesis that the regulatory β1 subunit is
essential for the activation of BK channels by tamoxifen, 4-OH tamoxifen (a major
biologically active metabolite), and 17β-estradiol in native myocytes. Patch clamp recordings …