Synthesis and biological activity of vitamin D2 3β-glucosiduronate and vitamin D2 3β-sulfate: Role of vitamin D2 conjugates in calcium homeostasis
R Kumar, JM Londowski, MP Murari - Journal of Steroid Biochemistry, 1982 - Elsevier
To ascertain the physiologic function of vitamin D 2 conjugates in calcium homeostasis, we
synthesized vitamin D 2 3β-glucosiduronate and vitamin D 2 3β-sulfate in pure form and
tested their biological activity in vitamin D deficient rats fed a low calcium diet. Vitamin D 2
3β-glucosiduronate was active in promoting calcium transport in the intestine at a dose of
100 pmol per rat. It increased calcium mobilization from bone and soft tissue at a dose of
1000 pmol per rat. This conjugate was less active than equimolar doses of vitamin D 2 …
synthesized vitamin D 2 3β-glucosiduronate and vitamin D 2 3β-sulfate in pure form and
tested their biological activity in vitamin D deficient rats fed a low calcium diet. Vitamin D 2
3β-glucosiduronate was active in promoting calcium transport in the intestine at a dose of
100 pmol per rat. It increased calcium mobilization from bone and soft tissue at a dose of
1000 pmol per rat. This conjugate was less active than equimolar doses of vitamin D 2 …