[HTML][HTML] Molecular dissection of actopaxin-integrin-linked kinase-Paxillin interactions and their role in subcellular localization
SN Nikolopoulos, CE Turner - Journal of Biological Chemistry, 2002 - ASBMB
Paxillin is a focal adhesion adapter protein involved in integrin signaling. We have recently
reported that the paxillin LD1 motif acts as a binding interface for both the actin-binding
protein actopaxin and the serine/threonine integrin-linked kinase (ILK). In this report we
demonstrate the direct association between actopaxin and ILK and dissect the role of the
respective interactions in their subcellular localization. Co-immunoprecipitation experiments
were employed to map the binding sites on ILK and actopaxin. ILK binds to the CH2 domain …
reported that the paxillin LD1 motif acts as a binding interface for both the actin-binding
protein actopaxin and the serine/threonine integrin-linked kinase (ILK). In this report we
demonstrate the direct association between actopaxin and ILK and dissect the role of the
respective interactions in their subcellular localization. Co-immunoprecipitation experiments
were employed to map the binding sites on ILK and actopaxin. ILK binds to the CH2 domain …