[HTML][HTML] Transforming Growth Factor-ॆ1 Potentiates Renal Tubular Epithelial Cell Death by a Mechanism Independent of Smad Signaling
C Dai, J Yang, Y Liu - Journal of biological chemistry, 2003 - ASBMB
Tubular atrophy resulting from epithelial cell loss is one of the characteristic features in the
development of chronic renal interstitial fibrosis. Although the trigger (s) and mechanism for
tubular cell loss remain undefined, the hyperactive transforming growth factor (TGF)-ॆ1
signaling has long been suspected to play an active role. Here we demonstrate that
although TGF-ॆ1 did not induce cell death per se, it dramatically potentiated renal tubular
cell apoptosis initiated by other death cues in vitro. Pre-incubation of human kidney …
development of chronic renal interstitial fibrosis. Although the trigger (s) and mechanism for
tubular cell loss remain undefined, the hyperactive transforming growth factor (TGF)-ॆ1
signaling has long been suspected to play an active role. Here we demonstrate that
although TGF-ॆ1 did not induce cell death per se, it dramatically potentiated renal tubular
cell apoptosis initiated by other death cues in vitro. Pre-incubation of human kidney …