How does adenosine inhibit transmitter release?
BB Fredholm, TV Dunwiddie - Trends in pharmacological sciences, 1988 - Elsevier
BB Fredholm, TV Dunwiddie
Trends in pharmacological sciences, 1988•ElsevierAdenosine is able to decrease the release of most neurotransmitters. This is consistent with
its general role in adjusting the rate of energy consumption to the metabolic supply in a
tissue. Bertil Fredholm and Tom Dunwiddie discuss the mechanisms behind the presynaptic
inhibitory action of adenosine. By stimulating receptors similar to A 1-receptors, adenosine
can inhibit adenylate cyclase, open K+ channels and reduce flux through Ca 2+ channels. It
is suggested that adenosine may depress transmitter release in several ways and that the …
its general role in adjusting the rate of energy consumption to the metabolic supply in a
tissue. Bertil Fredholm and Tom Dunwiddie discuss the mechanisms behind the presynaptic
inhibitory action of adenosine. By stimulating receptors similar to A 1-receptors, adenosine
can inhibit adenylate cyclase, open K+ channels and reduce flux through Ca 2+ channels. It
is suggested that adenosine may depress transmitter release in several ways and that the …
Abstract
Adenosine is able to decrease the release of most neurotransmitters. This is consistent with its general role in adjusting the rate of energy consumption to the metabolic supply in a tissue. Bertil Fredholm and Tom Dunwiddie discuss the mechanisms behind the presynaptic inhibitory action of adenosine. By stimulating receptors similar to A1-receptors, adenosine can inhibit adenylate cyclase, open K+ channels and reduce flux through Ca2+ channels. It is suggested that adenosine may depress transmitter release in several ways and that the relative importance of these presynaptic actions may vary between nerve terminals.
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