The peroxisome proliferator activated receptor regulates malic enzyme gene expression.
H Castelein, T Gulick, PE Declercq… - Journal of Biological …, 1994 - ASBMB
A new regulatory element for peroxisome proliferator activated receptor (PPAR)/retinoid X
receptor (RXR) heterodimers was found in the promoter of the malic enzyme gene. Similar to
previously characterized peroxisome proliferator response elements (PPREs), it consists of
a direct repeat of sequences related to the half-site consensus AGGTCA with an
interspacing of 1 base pair. Specific binding of PPAR/RXR heterodimers to this element was
demonstrated. Furthermore, this sequence conferred ciprofibrate responsiveness of a …
receptor (RXR) heterodimers was found in the promoter of the malic enzyme gene. Similar to
previously characterized peroxisome proliferator response elements (PPREs), it consists of
a direct repeat of sequences related to the half-site consensus AGGTCA with an
interspacing of 1 base pair. Specific binding of PPAR/RXR heterodimers to this element was
demonstrated. Furthermore, this sequence conferred ciprofibrate responsiveness of a …