Diabetic KKAy mice exhibit increased hepatic PPARγ1 gene expression and develop hepatic steatosis upon chronic treatment with antidiabetic thiazolidinediones
M Bedoucha, E Atzpodien, UA Boelsterli - Journal of hepatology, 2001 - Elsevier
Background/Aims: Peroxisome proliferator-activated receptor-γ, which is involved in the
regulation of lipid homeostasis, is upregulated in the liver of obese and diabetic mice, but
the biological consequences of this induction are largely unknown. This study was aimed at
further characterizing this upregulation and exploring the downstream biological effects of
specific activators on hepatic lipid metabolism. Methods: Hepatic expression of peroxisome
proliferator-activated receptor-γ1 and γ2 mRNA and protein was analyzed by real-time …
regulation of lipid homeostasis, is upregulated in the liver of obese and diabetic mice, but
the biological consequences of this induction are largely unknown. This study was aimed at
further characterizing this upregulation and exploring the downstream biological effects of
specific activators on hepatic lipid metabolism. Methods: Hepatic expression of peroxisome
proliferator-activated receptor-γ1 and γ2 mRNA and protein was analyzed by real-time …