T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching
The Journal of experimental medicine, 1998•rupress.org
The respective production of specific immunoglobulin (Ig) G2a or IgG1 within 5 d of primary
immunization with Swiss type mouse mammary tumor virus [MMTV (SW)] or haptenated
protein provides a model for the development of T helper 1 (Th1) and Th2 responses. The
antibody-producing cells arise from cognate T cell B cell interaction, revealed by the
respective induction of Cγ2a and Cγ1 switch transcript production, on the third day after
immunization. T cell proliferation and upregulation of mRNA for interferon γ in response to …
immunization with Swiss type mouse mammary tumor virus [MMTV (SW)] or haptenated
protein provides a model for the development of T helper 1 (Th1) and Th2 responses. The
antibody-producing cells arise from cognate T cell B cell interaction, revealed by the
respective induction of Cγ2a and Cγ1 switch transcript production, on the third day after
immunization. T cell proliferation and upregulation of mRNA for interferon γ in response to …
The respective production of specific immunoglobulin (Ig)G2a or IgG1 within 5 d of primary immunization with Swiss type mouse mammary tumor virus [MMTV(SW)] or haptenated protein provides a model for the development of T helper 1 (Th1) and Th2 responses. The antibody-producing cells arise from cognate T cell B cell interaction, revealed by the respective induction of Cγ2a and Cγ1 switch transcript production, on the third day after immunization. T cell proliferation and upregulation of mRNA for interferon γ in response to MMTV(SW) and interleukin 4 in response to haptenated protein also starts during this day. It follows that there is minimal delay in these responses between T cell priming and the onset of cognate interaction between T and B cells leading to class switching and exponential growth. The Th1 or Th2 profile is at least partially established at the time of the first cognate T cell interaction with B cells in the T zone.
The addition of killed Bordetella pertussis to the hapten–protein induces nonhapten-specific IgG2a and IgG1 plasma cells, whereas the anti-hapten response continues to be IgG1 dominated. This indicates that a Th2 response to hapten–protein can proceed in a node where there is substantial Th1 activity.
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