Differential effects of the immunosuppressive macrolides FK-506 and rapamycin on activation-induced T-cell apoptosis
MJ Staruch, NH Sigal, FJ Dumont - International journal of …, 1991 - Elsevier
Activation of certain T-cell induces, besides lymphokine production, a suicide process
(adoptosis) mediated by fragmentation of the cell's genome. This also occurs intrathymically
during negative selection of the T-cell receptor (TcR) repertoire. Cyclosporin A (CsA) has
been shown to block activation-driven T-cell apoptosis, an effect which may account for the
perturbations of TcR repertoire selection caused by this agent in vivo. Recently, the
macrolide FK-506 was demonstrated to suppress T-cell activation by inhibiting lymphokine …
(adoptosis) mediated by fragmentation of the cell's genome. This also occurs intrathymically
during negative selection of the T-cell receptor (TcR) repertoire. Cyclosporin A (CsA) has
been shown to block activation-driven T-cell apoptosis, an effect which may account for the
perturbations of TcR repertoire selection caused by this agent in vivo. Recently, the
macrolide FK-506 was demonstrated to suppress T-cell activation by inhibiting lymphokine …