[HTML][HTML] Homo-and heterodimerization of peroxisomal ATP-binding cassette half-transporters
LX Liu, K Janvier, V Berteaux-Lecellier, N Cartier… - Journal of Biological …, 1999 - ASBMB
Mammalian peroxisomal proteins adrenoleukodystrophy protein (ALDP),
adrenoleukodystrophy-related protein (ALDRP), and 70-kDa peroxisomal protein (PMP70)
belong to the superfamily of ATP-binding cassette (ABC) transporters. Unlike many ABC
transporters that are single functional proteins with two related halves, ALDP, ALDRP, and
PMP70 have the structure of ABC half-transporters. The dysfunction of ALDP is responsible
for X-linked adrenoleukodystrophy (X-ALD), a neurodegenerative disorder in which …
adrenoleukodystrophy-related protein (ALDRP), and 70-kDa peroxisomal protein (PMP70)
belong to the superfamily of ATP-binding cassette (ABC) transporters. Unlike many ABC
transporters that are single functional proteins with two related halves, ALDP, ALDRP, and
PMP70 have the structure of ABC half-transporters. The dysfunction of ALDP is responsible
for X-linked adrenoleukodystrophy (X-ALD), a neurodegenerative disorder in which …
