[HTML][HTML] Interleukin-15 prevents mouse mast cell apoptosis through STAT6-mediated Bcl-xL expression
A Masuda, T Matsuguchi, K Yamaki… - Journal of Biological …, 2001 - ASBMB
Interleukin (IL)-15 is a member of the cytokine family with T and natural killer (NK) cell
growth-promoting activity. In mast cells, however, IL-15 uses a distinct receptor system
different from that used in T and NK cells. We recently reported that IL-15 induces STAT6
activation and IL-4 production in a mouse mast cell line (MC/9) and bone marrow-derived
mast cells. In the present study, we have demonstrated that IL-15 prevents MC/9 and bone
marrow-derived mast cell apoptosis induced by factor withdrawal or anti-Fas antibody …
growth-promoting activity. In mast cells, however, IL-15 uses a distinct receptor system
different from that used in T and NK cells. We recently reported that IL-15 induces STAT6
activation and IL-4 production in a mouse mast cell line (MC/9) and bone marrow-derived
mast cells. In the present study, we have demonstrated that IL-15 prevents MC/9 and bone
marrow-derived mast cell apoptosis induced by factor withdrawal or anti-Fas antibody …