Matrix metalloproteinase 2 (gelatinase A) regulates glomerular mesangial cell proliferation and differentiation
J Turck, AS Pollock, LK Lee, HP Marti… - Journal of Biological …, 1996 - ASBMB
A biologic role for the 72-kDa gelatinase A (matrix metalloproteinase 2; MMP-2), beyond
simple extracellular matrix turnover, was evaluated in glomerular mesangial cells. To
determine the significance of MMP-2 secretion for the acquisition of the inflammatory
phenotype, we reduced the constitutive secretion of MMP-2 by cultured mesangial cells with
antisense RNA expressed by an episomally replicating vector or with specific anti-MMP-2
ribozymes expressed by a retroviral transducing vector. The phenotype of the transfected, or …
simple extracellular matrix turnover, was evaluated in glomerular mesangial cells. To
determine the significance of MMP-2 secretion for the acquisition of the inflammatory
phenotype, we reduced the constitutive secretion of MMP-2 by cultured mesangial cells with
antisense RNA expressed by an episomally replicating vector or with specific anti-MMP-2
ribozymes expressed by a retroviral transducing vector. The phenotype of the transfected, or …
