Induction of autoreactive B cells allows priming of autoreactive T cells.
RH Lin, MJ Mamula, JA Hardin… - The Journal of …, 1991 - rupress.org
RH Lin, MJ Mamula, JA Hardin, CA Janeway Jr
The Journal of experimental medicine, 1991•rupress.orgA novel mechanism for breaking T cell self tolerance is described. B cells induced to make
autoantibody by immunization of mice with the non-self protein human cytochrome c can
present the self protein mouse cytochrome c to autoreactive T cells in immunogenic form.
This mechanism of breaking T cell self tolerance could account for the role of foreign
antigens in breaking not only B cell but also T cell self tolerance, leading to sustained
autoantibody production in the absence of the foreign antigen.
autoantibody by immunization of mice with the non-self protein human cytochrome c can
present the self protein mouse cytochrome c to autoreactive T cells in immunogenic form.
This mechanism of breaking T cell self tolerance could account for the role of foreign
antigens in breaking not only B cell but also T cell self tolerance, leading to sustained
autoantibody production in the absence of the foreign antigen.
A novel mechanism for breaking T cell self tolerance is described. B cells induced to make autoantibody by immunization of mice with the non-self protein human cytochrome c can present the self protein mouse cytochrome c to autoreactive T cells in immunogenic form. This mechanism of breaking T cell self tolerance could account for the role of foreign antigens in breaking not only B cell but also T cell self tolerance, leading to sustained autoantibody production in the absence of the foreign antigen.
rupress.org