Five human mature B cell subsets
YJ Liu, O de Bouteiller, C Arpin, I Durand… - In Vivo Immunology …, 1994 - Springer
YJ Liu, O de Bouteiller, C Arpin, I Durand, J Banchereau
In Vivo Immunology: Regulatory Processes during Lymphopoiesis and Immunopoiesis, 1994•SpringerSecondary lymphoid organs display B lymphocytes at distinct stages of differentiation as a
consequence of ongoing antigenic stimulation. In order to understand the molecular
mechanisms which regulate B cell differentiation from virgin B cells to either memory B cells
or plasma cells, it is important to isolate B cells at different stages during immune responses
in vivo. The working model (Fig. 1) is based on many in vivo experiments on the
microenvironments of B cell activations (1–3). It predicts 5 mature B cell stages. Bm1 (mature …
consequence of ongoing antigenic stimulation. In order to understand the molecular
mechanisms which regulate B cell differentiation from virgin B cells to either memory B cells
or plasma cells, it is important to isolate B cells at different stages during immune responses
in vivo. The working model (Fig. 1) is based on many in vivo experiments on the
microenvironments of B cell activations (1–3). It predicts 5 mature B cell stages. Bm1 (mature …
Abstract
Secondary lymphoid organs display B lymphocytes at distinct stages of differentiation as a consequence of ongoing antigenic stimulation. In order to understand the molecular mechanisms which regulate B cell differentiation from virgin B cells to either memory B cells or plasma cells, it is important to isolate B cells at different stages during immune responses in vivo. The working model (Fig. 1) is based on many in vivo experiments on the microenvironments of B cell activations (1–3). It predicts 5 mature B cell stages. Bm1 (mature B cell subsets 1) represents virgin B cells; Bm2 ligand selected B cells (4), Bm3 germinal center centroblasts, Bm4 centrocytes and Bm5 memory B cells. Here we report on the identification and isolation of these B cell subsets from human tonsils.
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